Open AccessShape of the glucose response curve during an oral glucose tolerance test is associated with insulin clearance and muscle insulin sensitivity in healthy non‐obese men
Author(s) -
Kaga Hideyoshi,
Tamura Yoshifumi,
Takeno Kageumi,
Kakehi Saori,
Someya Yuki,
Funayama Takashi,
Furukawa Yasuhiko,
Suzuki Ruriko,
Sugimoto Daisuke,
Kadowaki Satoshi,
NishitaniYokoyama Miho,
Shimada Kazunori,
Daida Hiroyuki,
Aoki Shigeki,
Giacca Adria,
Sato Hiroaki,
Kawamori Ryuzo,
Watada Hirotaka
Publication year - 2020
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13227
Subject(s) - medicine , endocrinology , insulin , insulin sensitivity , adipose tissue , diabetes mellitus , type 2 diabetes , glucose tolerance test , insulin resistance , glucose clamp technique , area under the curve , clamp , mechanical engineering , clamping , engineering
Individuals with a monophasic glucose response curve (GRC) during a 75‐g oral glucose tolerance test have a higher risk for type 2 diabetes than those with a biphasic GRC. However, no studies have addressed the association between GRC type and insulin clearance. Thus, we studied 49 healthy non‐obese Japanese men. We divided study participants into the monophasic or biphasic group based on the shape of their GRC. We evaluated tissue‐specific insulin sensitivity and insulin clearance using a two‐step hyperinsulinemic‐euglycemic clamp. The monophasic group had more visceral fat, lower insulin clearance and lower muscle insulin sensitivity than the biphasic group, whereas liver and adipose tissue insulin sensitivity, and insulin secretion were comparable. In conclusion, healthy non‐obese men with a monophasic GRC have lower insulin clearance and muscle insulin sensitivity.