Open AccessPancreatic β‐cells express major histocompatibility complex class II: Do diabetic β‐cells have the capacity of antigen‐presenting cells?
Author(s) -
Sano Hiroyuki,
Imagawa Akihisa
Publication year - 2020
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13155
Subject(s) - major histocompatibility complex , mhc class ii , antigen presentation , immunology , ciita , cd8 , mhc class i , antigen , cytotoxic t cell , biology , antigen presenting cell , pancreatic islets , cd1 , t cell , immune system , interleukin 21 , endocrinology , islet , diabetes mellitus , genetics , in vitro
Russell et al . showed that major histocompatibility complex class II is expressed in pancreatic β‐cells by a highly accurate method called transcriptome analysis. Pancreatic β‐cells might have the capacity as antigen‐presenting cells.