Open AccessNew concept of the glucagon‐like peptide‐1 signaling pathway on pancreatic insulin secretion
Author(s) -
Kaku Kohei
Publication year - 2020
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13136
Subject(s) - protein kinase a , cyclic adenosine monophosphate , signal transduction , protein kinase c , adenosine , microbiology and biotechnology , phospholipase c , medicine , camp dependent pathway , intracellular , endocrinology , receptor , kinase , biology
The intracellular glucagon‐like peptide‐1 (GLP‐1) signaling pathway, which involves cyclic adenosine monophosphate (cAMP), exchange protein directly activated by cAMP, cAMP‐dependent protein kinase A (PKA) and adenosine triphosphate‐sensitive potassium channels, has been widely accepted as a common mechanism of GLP‐1‐stimulated insulin secretion. Recent studies showed that a stimulatory effect of GLP‐1 is also mediated by cAMP/PKA‐independent mechanisms, including induction of Gαq activity followed by phospholipase C and protein kinase C activation. Furthermore, transient receptor potential 4 and transient receptor potential 5 channels play a role in protein kinase C‐induced Ca 2+ current. This pathway is a unique action mechanism of GLP‐1 at physiologically low concentrations.