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Aims/Introduction  Sulfonylurea‐related hypoglycemia increases the risk of cardiovascular sequela, such as cardiac arrhythmia. This study aimed to clarify the relationship between the level of glycated hemoglobin (HbA 1c ) and the duration of hypoglycemia in type 2 diabetes patients treated with sulfonylureas.    Materials and Methods  Glucose levels in the enrolled patients ( n  =   300) were investigated with a professional continuous glucose monitoring device in the outpatient setting at six diabetes centers in Japan.    Results  A total of 269 participants completed the study. The duration of hypoglycemia with glucose values of <54 mg/dL was significantly longer in patients with an HbA 1c  level of ≤6.4% than in those with an HbA 1c  level of ≥8.0%, and that of hypoglycemia with glucose values of <70 mg/dL was significantly longer in patients with an HbA 1c  level of ≤6.4%, 6.5–6.9% or 7.0–7.4% than in those with an HbA 1c  level of ≥8.0%. Patients with an HbA 1c  level of ≤6.4% were exposed to glucose values of <70 mg/dL for >10% of the time in daily life (6.8 ± 5.6 min/h). The duration of hypoglycemia with glucose values of <70 mg/dL was longer at night than during the daytime, and the nadir of glucose values occurred between 03.00 and 05.00 hours irrespective of HbA 1c  level. The duration of hypoglycemia was associated with the duration of diabetes and sulfonylurea dose.    Conclusions  The duration of hypoglycemia was inversely correlated with HbA 1c  level and was longer during the night‐time than daytime in type 2 diabetes patients treated with sulfonylureas.

journal of diabetes investigation

Relationship between glycated hemoglobin level and duration of hypoglycemia in type 2 diabetes patients treated with sulfonylureas: A multicenter cross‐sectional study