Open AccessRelationship between glycated hemoglobin level and duration of hypoglycemia in type 2 diabetes patients treated with sulfonylureas: A multicenter cross‐sectional study
Author(s) -
Matsuoka Atsuko,
Hirota Yushi,
Takeda Akihiko,
Kishi Minoru,
Hashimoto Naoko,
Ohara Takeshi,
Higo Satomi,
Yamada Hiroyuki,
Nakamura Tomoaki,
Hamaguchi Tetsushi,
Takeuchi Takehito,
Nakagawa Yasushi,
Okada Yuko,
Sakaguchi Kazuhiko,
Ogawa Wataru
Publication year - 2020
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13132
Subject(s) - medicine , hypoglycemia , glycated hemoglobin , diabetes mellitus , sulfonylurea , type 2 diabetes , hemoglobin , endocrinology , repaglinide , type 1 diabetes
Aims/Introduction Sulfonylurea‐related hypoglycemia increases the risk of cardiovascular sequela, such as cardiac arrhythmia. This study aimed to clarify the relationship between the level of glycated hemoglobin (HbA 1c ) and the duration of hypoglycemia in type 2 diabetes patients treated with sulfonylureas. Materials and Methods Glucose levels in the enrolled patients ( n = 300) were investigated with a professional continuous glucose monitoring device in the outpatient setting at six diabetes centers in Japan. Results A total of 269 participants completed the study. The duration of hypoglycemia with glucose values of <54 mg/dL was significantly longer in patients with an HbA 1c level of ≤6.4% than in those with an HbA 1c level of ≥8.0%, and that of hypoglycemia with glucose values of <70 mg/dL was significantly longer in patients with an HbA 1c level of ≤6.4%, 6.5–6.9% or 7.0–7.4% than in those with an HbA 1c level of ≥8.0%. Patients with an HbA 1c level of ≤6.4% were exposed to glucose values of <70 mg/dL for >10% of the time in daily life (6.8 ± 5.6 min/h). The duration of hypoglycemia with glucose values of <70 mg/dL was longer at night than during the daytime, and the nadir of glucose values occurred between 03.00 and 05.00 hours irrespective of HbA 1c level. The duration of hypoglycemia was associated with the duration of diabetes and sulfonylurea dose. Conclusions The duration of hypoglycemia was inversely correlated with HbA 1c level and was longer during the night‐time than daytime in type 2 diabetes patients treated with sulfonylureas.