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Aims/Introduction  Resistin is an adipocyte‐derived polypeptide that leads to the progression of insulin resistance and subsequent atherosclerosis. Some studies have reported an association between self‐reported intake of  n −3 polyunsaturated fatty acids ( PUFA s) and serum resistin levels. However, no studies have investigated the association between the ratio of serum levels of  n −3 to serum  n −6  PUFA s and the serum resistin concentration in the general population.    Materials and Methods  We carried out a cross‐sectional study of 3,200 community‐dwelling Japanese individuals aged ≥40 years in 2002–2003. The ratios of serum eicosapentaenoic acid or docosahexaenoic acid to arachidonic acid ( AA ) were categorized into quartiles. The associations of serum  eicosapentaenoic acid / AA  and  docosahexaenoic acid / AA  with the serum resistin concentration were assessed using linear regression models with adjustment for potential confounding factors.    Results  The geometric mean of serum resistin was 10.3 ng/ mL . The age‐ and sex‐adjusted geometric mean of serum resistin decreased significantly with increased levels of serum  eicosapentaenoic acid / AA  (quartile 1: 11.3 ng/ mL ; quartile 2: 10.6 ng/ mL ; quartile 3: 10.3 ng/ mL ; quartile 4: 9.3 ng/ mL ;  P  for trend <0.001). A similar association was observed for serum  docosahexaenoic acid / AA  (quartile 1: 11.1 ng/ mL ; quartile 2: 10.6 ng/ mL ; quartile 3: 10.1 ng/ mL ; quartile 4: 9.7 ng/ mL ;  P  for trend <0.001). An adjustment for potential confounding factors did not change these associations.    Conclusions  Higher ratios of serum  n −3 to  n −6  PUFA s were associated with lower serum resistin levels. Consumption of a large amount of  n −3  PUFA s might have desirable effects on resistin‐mediated diseases.

journal of diabetes investigation

Ratios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely associated with serum resistin levels: The Hisayama Study