Open AccessRatios of serum eicosapentaenoic acid to arachidonic acid and docosahexaenoic acid to arachidonic acid were inversely associated with serum resistin levels: The Hisayama Study
Author(s) -
Higashioka Mayu,
Hirakawa Yoichiro,
Kawamura Ryoichi,
Honda Takanori,
Hata Jun,
Yoshida Daigo,
Takata Yasunori,
Kitazono Takanari,
Osawa Haruhiko,
Ninomiya Toshiharu
Publication year - 2020
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13129
Subject(s) - docosahexaenoic acid , eicosapentaenoic acid , resistin , medicine , quartile , arachidonic acid , endocrinology , polyunsaturated fatty acid , confounding , fatty acid , insulin resistance , chemistry , insulin , adiponectin , biochemistry , confidence interval , enzyme
Aims/Introduction Resistin is an adipocyte‐derived polypeptide that leads to the progression of insulin resistance and subsequent atherosclerosis. Some studies have reported an association between self‐reported intake of n −3 polyunsaturated fatty acids ( PUFA s) and serum resistin levels. However, no studies have investigated the association between the ratio of serum levels of n −3 to serum n −6 PUFA s and the serum resistin concentration in the general population. Materials and Methods We carried out a cross‐sectional study of 3,200 community‐dwelling Japanese individuals aged ≥40 years in 2002–2003. The ratios of serum eicosapentaenoic acid or docosahexaenoic acid to arachidonic acid ( AA ) were categorized into quartiles. The associations of serum eicosapentaenoic acid / AA and docosahexaenoic acid / AA with the serum resistin concentration were assessed using linear regression models with adjustment for potential confounding factors. Results The geometric mean of serum resistin was 10.3 ng/ mL . The age‐ and sex‐adjusted geometric mean of serum resistin decreased significantly with increased levels of serum eicosapentaenoic acid / AA (quartile 1: 11.3 ng/ mL ; quartile 2: 10.6 ng/ mL ; quartile 3: 10.3 ng/ mL ; quartile 4: 9.3 ng/ mL ; P for trend <0.001). A similar association was observed for serum docosahexaenoic acid / AA (quartile 1: 11.1 ng/ mL ; quartile 2: 10.6 ng/ mL ; quartile 3: 10.1 ng/ mL ; quartile 4: 9.7 ng/ mL ; P for trend <0.001). An adjustment for potential confounding factors did not change these associations. Conclusions Higher ratios of serum n −3 to n −6 PUFA s were associated with lower serum resistin levels. Consumption of a large amount of n −3 PUFA s might have desirable effects on resistin‐mediated diseases.