English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Aims/Introduction  Pharmacological levels of glucagon‐like peptide‐1 (GLP‐1) can decelerate gastric emptying (GE) and reduce postprandial glucose levels. Most previous studies have used liquid meals to evaluate GE. We evaluated the effects of GLP‐1 receptor agonists (GLP‐1 RAs) on GE and postprandial glucose excursion in Japanese type 2 diabetes mellitus patients using a combination of solid and liquid meals.    Materials and Methods  In this single‐center, prospective, open‐label study, nine healthy individuals and 17 patients with type 2 diabetes mellitus consumed a 460‐kcal combination of a solid and liquid meal labeled with  13 C‐acetic acid. GE was measured from  t  = 0 to 150 min in a continuous  13 C breath test. Eight participants with type 2 diabetes mellitus were administered GLP‐1 RAs, and we examined the relationship between GE and blood glucose excursion.    Results  There were no differences in the average GE coefficient (GEC) and lag time between the healthy and type 2 diabetes mellitus groups. However, the type 2 diabetes mellitus group showed larger GEC variations ( P <  0.05). The coefficient of variation of R‐R intervals was a significant predictor of GEC in type 2 diabetes mellitus patients ( P  <   0.01). The short‐acting GLP‐1 RA reduced the GEC at 1 month ( P  =   0.012), whereas the long‐acting GLP‐1 RA did not significantly change the GEC after treatment. A positive relationship was observed between postprandial glucose excursion from  T  0 min  to  T  60 min  and the GEC ( r   2   = 0.75;  P  <   0.01).    Conclusions  The reduction in GE rate by the administration of GLP‐1 RAs can predict the improvement in postprandial glucose excursion in type 2 diabetes mellitus patients .

journal of diabetes investigation

Magnitude of slowing gastric emptying by glucagon‐like peptide‐1 receptor agonists determines the amelioration of postprandial glucose excursion in Japanese patients with type 2 diabetes