Open AccessLower body mass index is not of more benefit for diabetic complications
Author(s) -
Zhang Yongze,
Guo Yangyang,
Shen Ximei,
Zhao Fengying,
Yan Sunjie
Publication year - 2019
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.13003
Subject(s) - medicine , body mass index , diabetes mellitus , type 2 diabetes , odds ratio , percentile , confounding , type 2 diabetes mellitus , kidney disease , cardiology , endocrinology , mathematics , statistics
Aims/Introduction To investigate the relationship between different body mass index ( BMI ) levels and vascular complications in type 2 diabetes mellitus patients. Materials and Methods Data were collected from 3,224 individuals with type 2 diabetes mellitus (male/female: 1,635/1,589; age 61.31 ± 11.45 years), using a retrospective case study design. The association of BMI quintiles and diabetes mellitus vascular complications was assessed using multiple logistic regression models adjusting for age, sex, diabetes duration, smoking status, drinking and other confounders, using those with the lowest quintile of BMI as the reference group. Results With increasing BMI , the detection rate of diabetic peripheral neuropathy and peripheral arterial disease initially decreased and then it increased, whereas the detection rate of diabetic kidney disease and carotid atherosclerotic plaques showed an upward trend; however, diabetic retinopathy was irregular. The odds ratios of diabetic peripheral neuropathy decreased as BMI increased from the 21st percentile to the 80th percentile initially, and increased when BMI was in >80th percentile. The same result was shown in peripheral arterial disease . BMI >80th percentile showed a 1.426‐fold risk of diabetic kidney disease and a 1.336 ‐fold risk of carotid atherosclerotic plaque. Conclusions In patients with type 2 diabetes mellitus, the relationship between different BMI s and vascular complications varies. A U‐shaped relationship was observed between BMI and diabetic peripheral neuropathy, as well as BMI and peripheral arterial disease . BMI is positively correlated with diabetic kidney disease and carotid atherosclerotic plaque; however, it is not correlated with diabetic retinopathy .