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Cardiorenal protective effects of sodium–glucose cotransporter 2 inhibitors are difficult to explain. From the recent works by Takagi  et al . and an expert consensus report, I suggest further works on the effects of sodium–glucose cotransporter 2inhibitors on mitochondrial function could help to understand this very interesting development.

Cardiorenal protective effect of sodium–glucose cotransporter 2 inhibitors and mitochondrial function