Open AccessIndependent links between plasma xanthine oxidoreductase activity and levels of adipokines
Author(s) -
Furuhashi Masato,
Matsumoto Megumi,
Murase Takayo,
Nakamura Takashi,
Higashiura Yukimura,
Koyama Masayuki,
Tanaka Marenao,
Moniwa Norihito,
Ohnishi Hirofumi,
Saitoh Shigeyuki,
Shimamoto Kazuaki,
Miura Tetsuji
Publication year - 2019
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12982
Subject(s) - medicine , endocrinology , insulin resistance , adipokine , adiponectin , uric acid , hyperuricemia , xanthine oxidase , body mass index , obesity , chemistry , biochemistry , enzyme
Aims/Introduction Xanthine oxidoreductase ( XOR ) is a rate‐limiting enzyme that catalyzes uric acid formation in the purine metabolism, is involved in an increase in reactive oxygen species. Plasma XOR activity has been shown to be associated with obesity, smoking, liver dysfunction, hyperuricemia, dyslipidemia and insulin resistance. Materials and Methods The association between plasma XOR activity, measured by using liquid chromatography and mass spectrometry, and levels of adipokines, including adiponectin, fatty acid‐binding protein 4 ( FABP 4) and fibroblast growth factor 21 ( FGF 21), was investigated in 282 participants (male/female: 126/156) of the Tanno‐Sobetsu Study who were not taking medication. Results Women had lower plasma XOR activity than did men. Smoking habit was associated with increased activity. Plasma XOR activity was positively correlated with concentrations of FABP 4 ( r = 0.192, P < 0.001) and FGF 21 ( r = 0.208, P < 0.001), homeostasis model assessment of insulin resistance as an index of insulin resistance and uric acid, and was negatively correlated with adiponectin level ( r = −0.243, P = 0.001). Multivariate regression analyses showed that levels of adiponectin, FABP 4 and FGF 21 were independent determinants of plasma XOR activity after adjusting age, sex, uric acid and homeostasis model assessment of insulin resistance. With additional adjustment of smoking habit, the level of FABP 4, but not that of adiponectin or FGF 21, remained as an independent predictor of plasma XOR activity. Conclusions Plasma XOR activity was independently associated with levels of adipokines in a general population of individuals not taking medication.