Open AccessEffects of endurance training on hippocampus DJ ‐1, cannabinoid receptor type 2 and blood glucose concentration in diabetic rats
Author(s) -
Kurd Mohammad,
Valipour Dehnou Vahid,
Tavakoli Seyed A,
Gahreman Daniel E
Publication year - 2019
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12868
Subject(s) - medicine , endocrinology , diabetes mellitus , hippocampus , endurance training , aerobic exercise , type 2 diabetes , cannabinoid , receptor
Aims/Introduction To investigate the effect of endurance training on hippocampus DJ ‐1 and cannabinoid receptor type 2 ( CB 2 ) protein and blood glucose concentration in diabetic rats. Materials and Methods A total of 32 rats were randomly divided into diabetic (D), diabetic and exercise ( DE ), exercise (E) and control (C) groups. The endurance training was carried out five times per week for 6 weeks. The hippocampus DJ ‐1 and CB 2 were measured using an enzyme‐linked immunosorbent assay method. Results The level of DJ ‐1 in the D group was significantly higher than the other groups ( P ≤ 0.01). However, the level of DJ ‐1 was not significantly different between the C, E and DE groups. In addition, the level of CB 2 was significantly lower in the D group compared with the other groups ( P ≤ 0.01). Blood glucose was significantly higher in the D group compared with the DE group ( P ≤ 0.05). Furthermore, a significant positive correlation between the level of DJ ‐1 and blood glucose was observed ( r = 0.67, P ≤ 0.001). There was also a significant inverse correlation between the level of CB 2 and blood glucose ( r = −0.77, P ≤ 0.001). Conclusions The results of this study suggest that the level of DJ ‐1 and CB 2 might change in response to diabetes, and regular aerobic exercise could mediate the effect of DJ ‐1 and CB 2 on diabetes‐induced neurodegenerative diseases.