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Aims/Introduction  Hypertension is one of the most significant risk factors for diabetes. The present study aimed to investigate the associations of lipid profiles, including the ratio of low‐density lipoprotein cholesterol ( LDL ‐C)‐to‐high‐density lipoprotein cholesterol ( HDL ‐C) and triglyceride ( TG ) levels, as well as their interactions, with type 2 diabetes in hypertensive patients.    Materials and Methods  Hypertensive patients without a history of diabetes and hypolipidemic agents were enrolled continuously at the Hypertension Clinic, Zhongshan Hospital, Fudan University (Shanghai, China) from 2014 to 2016. General clinical data, including body mass index, blood pressure, fasting glucose and 2‐h post‐load glucose levels, and lipid profiles, were collected. The  LDL ‐C/ HDL ‐C ratio,  TG / HDL ‐C ratio and  TC / HDL ‐C ratio were separately calculated. Statistical analyses were carried out by using  SPSS  software (version 13.0).    Results  In total, 935 hypertensive patients were included, of which 114 patients (12.2%) were diagnosed with diabetes. After multivariate adjustments, the  LDL ‐C/ HDL ‐C ratio and  TG  levels had the most significant and independent associations with diabetes. In the multivariate logistic regression, the  LDL ‐C/ HDL ‐C ratio and  TG  were independently associated with diabetes. After the interaction variable was included, the  LDL ‐C/ HDL ‐C ratio remained independently associated with diabetes, but  TG  was replaced by  TG * LDL ‐C/ HDL ‐C.    Conclusions  In conclusion, elevated  LDL ‐C/ HDL ‐C ratios and  TG  levels were associated with diabetes in patients with hypertension, with an interactive effect of the  LDL ‐C/ HDL ‐C ratio and  TG  on diabetes in the hypertensive population.

journal of diabetes investigation

Contribution and interaction of the low‐density lipoprotein cholesterol to high‐density lipoprotein cholesterol ratio and triglyceride to diabetes in hypertensive patients: A cross‐sectional study