Open AccessSex differences in insulin and glucagon responses for glucose homeostasis in young healthy Japanese adults
Author(s) -
Horie Ichiro,
Abiru Norio,
Eto Mami,
Sako Ayaka,
Akeshima Junya,
Nakao Tomoe,
Nakashima Yomi,
Niri Tetsuro,
Ito Ayako,
Nozaki Aya,
Haraguchi Ai,
Akazawa Satoru,
Mori Yoshitaka,
Ando Takao,
Kawakami Atsushi
Publication year - 2018
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12829
Subject(s) - medicine , glucagon , endocrinology , glucose homeostasis , diabetes mellitus , insulin , hormone , glucose tolerance test , homeostasis , insulin response , plasma glucose , insulin resistance
Abstract It has been reported that glucose responses during the oral glucose tolerance test differ between healthy women and men. However, it remains unknown what factors contribute to these differences between the sexes. The present study analyzed the insulin and glucagon responses during the oral glucose tolerance test in 25 female and 38 male healthy young adults aged 22–30 years. The plasma glucose levels at 120 min were significantly higher in women than men. Insulin secretion was significantly greater at 30, 90 and 120 min from baseline in women than men. Glucagon suppression was greater at 30 and 120 min from baseline in men than women when determined by a sandwich enzyme‐linked immunosorbent assay glucagon kit. These results suggest that the differences in glucose responses during the oral glucose tolerance test are mediated by the difference between the sexes in bi‐hormonal responses in healthy individuals.