Open AccessSerum adiponectin and insulin secretion: A direct or inverse association?
Author(s) -
Nakamura Akinobu,
Miyoshi Hideaki,
Ukawa Shigekazu,
Nakamura Koshi,
Nakagawa Takafumi,
Terauchi Yasuo,
Tamakoshi Akiko,
Atsumi Tatsuya
Publication year - 2018
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12821
Subject(s) - adiponectin , insulin resistance , medicine , endocrinology , confidence interval , insulin , diabetes mellitus , homeostasis , body mass index , population , quantitative insulin sensitivity check index , insulin sensitivity , environmental health
We investigated the association between serum high molecular weight ( HMW ) adiponectin and insulin secretion in a population‐based study, with or without adjustment for insulin sensitivity. A total of 488 participants (263 women) were included in the present study. Insulin secretion was estimated using the homeostasis model assessment of β‐cell function ± adjustment for insulin resistance using the disposition index. Multivariate analysis showed that HMW adiponectin was significantly and inversely associated with homeostasis model assessment of β‐cell function (partial regression coefficient −0.19, 95% confidence interval −0.28, −0.10, P < 0.0001). However, HMW adiponectin was significantly and positively associated with disposition index (partial regression coefficient 0.15, 95% confidence interval 0.06, 0.24, P = 0.0016). The present study showed that a positive association between HMW adiponectin levels and insulin secretion evaluated using an index incorporating adjustment for insulin resistance was identified, and vice versa using an index that did not adjust for insulin resistance.