English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Aims/Introduction  Member B of the family with sequence similarity 3 ( FAM 3B), also known as pancreatic‐derived factor, is mainly synthesized and secreted by islet β‐cells, and plays a role in abnormal metabolism of glucose and lipids. However, the prospective association of  FAM 3B with metabolic disorders remains unclear. The present study aimed to reveal the predictive relationship between pancreas‐specific cytokine and metabolic syndrome (MetS).    Materials and Methods  A total of 210 adults (88 men and 122 women) without MetS, aged between 40 and 65 years, were recruited and received a comprehensive health examination. Baseline serum  FAM 3B levels were determined by sandwich enzyme‐linked immunosorbent assay. Subsequently, all participants underwent a follow‐up examination after 5 years. MetS was identified in accordance with the International Diabetes Federation criteria.    Results  During follow up, 35.7% participants developed MetS. In comparison with the non‐MetS group, participants with MetS had an increased serum  FAM 3B at baseline (21.85 ng/ mL  [19.38, 24.17 ng/ mL ] vs 28.56 ng/ mL  [25.32, 38.10 ng/ mL ],  P  < 0.001). Moreover, serum  FAM 3B was significantly associated with variations in fasting plasma insulin ( r  = −0.306,  P  < 0.001), homeostasis model assessment of β‐cell function ( r  = −0.328,  P  < 0.001) and homeostasis model assessment of insulin resistance ( r  = −0.191,  P  = 0.006). Furthermore, a positive correlation between baseline  FAM 3B and the incidence of MetS was observed, even after multivariable adjustment (relative risk 1.23 [1.15, 1.31],  P  < 0.001). Furthermore, the optimal cut‐off values of  FAM 3B was 23.98 ng/ mL  for predicting MetS based on the Youden Index.    Conclusions  Elevated circulating  FAM 3B might be considered as a predictor of newly‐onset MetS and its progression.

journal of diabetes investigation

Effects of circulating member B of the family with sequence similarity 3 on the risk of developing metabolic syndrome and its components: A 5‐year prospective study