Open AccessEpigenetic dysregulation in pancreatic islets and pathogenesis of type 2 diabetes
Author(s) -
Yokoi Norihide
Publication year - 2018
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12724
Subject(s) - epigenetics , dna methylation , genetics , missing heritability problem , biology , histone , epigenomics , chromatin , gene , genotype , gene expression , single nucleotide polymorphism
Most of type 2 diabetes (T2D) is thought to be the result of interaction between genetic and environmental factors. However, the genetic components discovered to date can explain only a small proportion of the observed heritability. The “missing heritability” may be accounted for by rare variants, gene‐environment interactions, and epigenetics.