Open AccessMetabolomics window into diabetic complications
Author(s) -
Wu Tao,
Qiao Shuxuan,
Shi Chenze,
Wang Shuya,
Ji Guang
Publication year - 2018
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12723
Subject(s) - medicine , metabolomics , diabetes mellitus , diabetic nephropathy , diabetic retinopathy , pathogenesis , diabetic neuropathy , coronary artery disease , disease , bioinformatics , mechanism (biology) , nephropathy , endocrinology , philosophy , epistemology , biology
Diabetes has become a major global health problem. The elucidation of characteristic metabolic alterations during the diabetic progression is critical for better understanding its pathogenesis, and identifying potential biomarkers and drug targets. Metabolomics is a promising tool to reveal the metabolic changes and the underlying mechanism involved in the pathogenesis of diabetic complications. The present review provides an update on the application of metabolomics in diabetic complications, including diabetic coronary artery disease, diabetic nephropathy, diabetic retinopathy and diabetic neuropathy, and this review provides notes on the prevention and prediction of diabetic complications.