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Aims/Introduction  We compared the satisfaction levels of patients with type 2 diabetes undergoing combination therapy with lixisenatide ( LIX ) and basal insulin with that of patients undergoing multiple daily insulin injection ( MDI ) therapy.    Materials and Methods  The study was a 12‐week open‐label, randomized, multicenter, controlled trial. Participants were Japanese patients with type 2 diabetes receiving  MDI  for >3 months. Patients were randomly assigned to each treatment cohort: (i) a group that continued  MDI  ( MDI  group); and (ii) a group that switched from  MDI  to combination therapy with  LIX  and basal insulin ( LIX  group). The primary outcome was change in Diabetes Treatment Satisfaction Questionnaire scores from baseline to 12 weeks between these two groups. Key secondary outcomes were glycated hemoglobin and body weight changes.    Results  A total of 31 patients were initially enrolled in the study, and 26 of them completed the study. The change in Diabetes Treatment Satisfaction Questionnaire scores in the  LIX  group was significantly greater compared with that in the  MDI  group. Mean changes in glycated hemoglobin levels were −0.05 ± 0.37% in the  MDI  group and 0.04 ± 0.38% in the  LIX  group ( P  = 0.36). Mean changes in body weight were +0.6 ± 1.8 kg in the  MDI  group and −2.5 ± 1.8 kg in the  LIX  group ( P  < 0.01).    Conclusions  Switching from  MDI  to combination therapy with  LIX  and basal insulin improved satisfaction levels while maintaining glycemic control in Japanese patients with type 2 diabetes.

journal of diabetes investigation

Satisfaction of switching to combination therapy with lixisenatide and basal insulin in patients with type 2 diabetes receiving multiple daily insulin injection therapy: A randomized controlled trial