Open AccessThe number of microvascular complications is associated with an increased risk for severity of periodontitis in type 2 diabetes patients: Results of a multicenter hospital‐based cross‐sectional study
Author(s) -
Nitta Hiroshi,
Katagiri Sayaka,
Nagasawa Toshiyuki,
Izumi Yuichi,
Ishikawa Isao,
Izumiyama Hajime,
Uchimura Isao,
Kanazawa Masao,
Chiba Hiroshige,
Matsuo Akira,
Utsunomiya Kazunori,
Tanabe Haruyasu,
Takei Izumi,
Asanami Soichiro,
Kajio Hiroshi,
Ono Toaki,
Hayashi Yoichi,
Ueki Kiichi,
Tsuji Masatomi,
Kurachi Yoichi,
Yamanouchi Toshikazu,
Ichinokawa Yoshimi,
Inokuchi Toshiki,
Fukui Akiko,
Miyazaki Shigeru,
Miyauchi Takashi,
Kawahara Reiko,
Ogiuchi Hideki,
Yoshioka Narihito,
Negishi Jun,
Mori Masatomo,
Mogi Kenji,
Saito Yasushi,
Tanzawa Hideki,
Nishikawa Tetsuo,
Takada Norihiko,
Nanjo Kishio,
Morita Nobuo,
Nakamura Naoto,
Kanamura Narisato,
Makino Hirofumi,
Nishimura Fusanori,
Kobayashi Kunihisa,
Higuchi Yoshinori,
Sakata Toshiie,
Yanagisawa Shigetaka,
Tei Chuwa,
Ando Yuichi,
Hanada Nobuhiro,
Inoue Shuji
Publication year - 2017
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12633
Subject(s) - medicine , glycated hemoglobin , periodontitis , odds ratio , glycemic , diabetes mellitus , confidence interval , type 2 diabetes , risk factor , gastroenterology , endocrinology
Aims/Introduction To explore the relationships between periodontitis and microvascular complications as well as glycemic control in type 2 diabetes patients. Materials and Methods This multicenter, hospital‐based, cross‐sectional study included 620 patients with type 2 diabetes. We compared the prevalence and severity of periodontitis between patients with ≥1 microvascular complication and those without microvascular complications. We also compared the prevalence and severity of periodontitis among patients with different degrees of glycemic control. Results After adjusting for confounding factors, multiple logistic regression analysis showed that the severity of periodontitis was significantly associated with the number of microvascular complications (odds ratio 1.3, 95% confidence interval 1.1–1.6), glycated hemoglobin ≥8.0% (64 mmol/mol; odds ratio 1.6; 95% confidence interval 1.1–2.3), and older age (≥50 years; odds ratio 1.7; 95% confidence interval 1.1–2.6). However, the prevalence of periodontitis was not significantly associated with the number of microvascular complications, but was associated with male sex, high glycated hemoglobin (≥8.0% [64 mmol/mol]), older age (≥40 years), longer duration of diabetes (≥15 years) and fewer teeth (≤25). Furthermore, propensity score matching for age, sex, diabetes duration and glycated hemoglobin showed that the incidence of severe periodontitis was significantly higher among patients with microvascular complications than among those without microvascular complications ( P < 0.05). Conclusions The number of microvascular complications is a risk factor for more severe periodontitis in patients with type 2 diabetes, whereas poor glycemic control is a risk factor for increased prevalence and severity of periodontitis.