Open AccessAssociation between TCF 7L2 polymorphisms and gestational diabetes mellitus: A meta‐analysis
Author(s) -
Chang Shaoyan,
Wang Zhen,
Wu Lihua,
Lu Xiaolin,
Shangguan Shaofang,
Xin Yu,
Li Li,
Wang Li
Publication year - 2017
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12612
Subject(s) - gestational diabetes , odds ratio , snp , meta analysis , single nucleotide polymorphism , medicine , genetics , genotype , biology , pregnancy , gene , gestation
Aims/Introduction Studies have been carried out to evaluate the correlation between TCF 7L2 genetic polymorphisms and gestational diabetes mellitus ( GDM ) risk. However, the conclusions from these studies are incomplete, because partial single nucleotide polymorphisms ( SNP s) were analyzed. We carried out a meta‐analysis aimed to systematically evaluate TCF 7L2 gene polymorphisms and GDM susceptibility in all population and racial/ethnic subgroups to afford a foundation for future research. Materials and Methods Published studies censoring TCF 7L2 variants and GDM risk were captured from the EMBASE , PubMed, CNKI and Wanfang databases. The meta‐analysis was processed using software of RevMan 5.2 and Stata13. The relationship between TCF 7L2 polymorphism and GDM occurrence was evaluated by pooled odds ratios. Stratified analysis based on race/ethnicity was also carried out. The allele‐specific odds ratios and 95% confidence intervals were counted, and based on homogeneity evaluated using the I 2 ‐test, fixed‐ or random‐effects pooled measures were selected. Results A total of 22 studies were covered, capturing eight TCF 7L2 SNP s and involving 5,573 cases and 13,266 controls. Six of eight SNP s showed significant relationships with GDM occurrence, of which the SNP s rs7903146, rs12255372 and rs7901695 were the most powerful. Stratified analysis by race/ethnicity showed discrepant results in these three SNP s. In Caucasians and other races, all these SNP s were found to have a significant association with GDM risk, but in Asians, only SNP rs7903146 showed a significant association. Conclusions Six of eight SNP s were found to have significant associations between TCF 7L2 variants and GDM risk in the overall population, with the most powerful in SNP s being rs7903146, rs12255372 and rs7901695, but the contribution of these SNP s to GDM risk were variable among different racial/ethnic groups.