Open AccessGlucose‐ or insulin resistance‐mediated β‐cell replication: PKC ζ integrates the proliferative signaling
Author(s) -
Shirakawa Jun,
Terauchi Yasuo
Publication year - 2017
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12558
Subject(s) - insulin resistance , medicine , protein kinase c , diabetes mellitus , signal transduction , replication (statistics) , microbiology and biotechnology , insulin receptor , insulin , endocrinology , virology , biology
Glucose‐ or insulin resistance‐mediated β‐cell replication serves as a useful physiological model of β‐cell mass expansion to study the pathophysiology of type 2 diabetes. Lakshmipathi et al. (2016) report that PKCζ activation is crucial for compensatory β‐cell proliferation induced by glucose stimulation or high‐fat diet‐feeding.