English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Aims/Introduction  To investigate the effect of telomere shortening and other predictive factors of non‐alcoholic fatty liver disease ( NAFLD ) in type 2 diabetes mellitus patients in a 6‐year prospective cohort study.    Materials and Methods  A total of 70 type 2 diabetes mellitus (mean age 57.8 ± 6.7 years) patients without  NAFLD  were included in the study, and 64 of them were successfully followed up 6 years later, excluding four cases with significant alcohol consumption.  NAFLD  was diagnosed by the hepatorenal ratio obtained by a quantitative ultrasound method using  NIH  image analysis software. The 39 individuals that developed  NAFLD  were allocated to group A, and the 21 individuals that did not develop  NAFLD  were allocated to group B. Fluorescent real‐time quantitative polymerase chain reaction was used to measure telomere length.    Results  There was no significant difference between the two groups in baseline telomere length; however, at the end of the 6th year, telomere length had become shorter in group A compared with group B. There were significant differences between these two groups in baseline body mass index, waistline, systolic blood pressure, glycated hemoglobin and fasting C‐peptide level. In addition, the estimated indices of baseline insulin resistance increased in group A. Fasting insulin level, body mass index, systolic blood pressure at baseline and the shortening of telomere length were independent risk factors of  NAFLD  in type 2 diabetes mellitus patients.    Conclusions  Telomere length became shorter in type 2 diabetes mellitus patients who developed  NAFLD  over the course of 6 years. Type 2 diabetes mellitus patients who developed  NAFLD  had more serious insulin resistance compared with those who did not develop  NAFLD  a long time ago.

journal of diabetes investigation

Deoxyribonucleic acid telomere length shortening can predict the incidence of non‐alcoholic fatty liver disease in patients with type 2 diabetes mellitus