Open AccessElevated expression levels of serum insulin‐like growth factor‐1, tumor necrosis factor‐α and vascular endothelial growth factor 165 might exacerbate type 2 diabetic nephropathy
Author(s) -
Li Xiang,
Wu TingTing,
Chen Juan,
Qiu Wen
Publication year - 2017
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12542
Subject(s) - microalbuminuria , medicine , endocrinology , vascular endothelial growth factor , diabetic nephropathy , creatinine , tumor necrosis factor alpha , nephropathy , diabetes mellitus , type 2 diabetes , growth factor , insulin like growth factor , vegf receptors , receptor
Aims/Introduction The present study aimed to determine the associations between expressions of insulin‐like growth factor‐1 ( IGF ‐1), tumor necrosis factor‐α ( TNF ‐α) and vascular endothelial growth factor 165 ( VEGF 165 ) in serum, and occurrence and development of type 2 diabetic nephropathy ( DN ). Materials and Methods A total of 108 patients diagnosed as DN were randomly selected, including 50 patients in the microalbuminuria group, 44 patients in the macroalbuminuria group and 14 patients in the renal insufficiency group. Meanwhile, 97 healthy people were collected as a normal control group. Urinary albumin ( UALB ) and urine creatinine (Cr) of all participants were measured for 24 h, with their ratio ( UALB /Cr) being calculated. Enzyme‐linked immunosorbent assay was used to detect the serum concentrations of IGF ‐1, TNF ‐α and VEGF 165 . Results The expressions of serum IGF ‐1, TNF ‐α and VEGF 165 in the type 2 DN patients were significantly higher than those in the control group (all P < 0.05). The expressions of serum IGF ‐1, TNF ‐α and VEGF 165 in the type 2 DN patients were positively correlated with UALB /Cr (all P < 0.05). As type 2 DN worsened, the expressions of serum IGF ‐1, TNF ‐α and VEGF 165 increased, and type 2 DN severity had positive correlations with serum IGF ‐1, TNF ‐α and VEGF 165 concentrations (all P < 0.05). There was a positive association between IGF ‐1 and TNF ‐α, IGF ‐1 and VEGF 165 , and TNF ‐α and VEGF 165 (all P < 0.05). Logistic regression analysis showed that IGF ‐1 and VEGF 165 were associated with the progression of DN (both P < 0.05). Conclusions Elevated expression levels of serum IGF ‐1, TNF ‐α and VEGF 165 might exacerbate type 2 DN .