Open AccessNovel mechanism for counter‐regulatory responses to hypoglycemia
Author(s) -
Himeno Tatsuhito,
Nakamura Jiro
Publication year - 2017
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12527
Subject(s) - medicine , mechanism (biology) , diabetes mellitus , hypoglycemia , over the counter , intensive care medicine , pharmacology , endocrinology , medical prescription , philosophy , epistemology
In the central nervous system, especially in the hypothalamus, the energy status in the body is assessed by glucose‐sensing neurons since glucose is the major fuel in the central nervous system. Glucose sensing mechanisms also have a significant role in prevention of hypoglycemic bouts. In a recent report, Fan and colleagues proved a novel type of glucose‐exited neurons which detect hypoglycemia through decreasing glucose entry via SGLT1.