English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Aims/Introduction  Our previous study found that dexamethasone‐induced insulin resistance ( IR ) was involved in 5‐hydroxytryptamine (5‐ HT ) synthesis and 5‐hydroxytryptamine 2 receptor (5‐ HT  2 R) in the periphery. The present study examined the effects of inhibitions of both peripheral 5‐ HT  synthesis and 5‐ HT  2 R on dexamethasone‐induced  IR .    Materials and Methods  Male rats were exposed to dexamethasone for 10 days, then treated with or without a 5‐ HT  2 R antagonist, sarpogrelate, a 5‐ HT  synthetic inhibitor, carbidopa, alone or in combination for 20 days.    Results  Dexamethasone‐induced whole‐body  IR , with glucose intolerance, decreased insulin sensitivity, hyperglycemia, hyperinsulinemia and dyslipidemia, could be effectively abolished by sarpogrelate or/and carbidopa, whereas  IR ‐related actions of dexamethasone in tissues were accompanied by increased 5‐ HT  synthesis in the liver and visceral adipose, and upregulated 5‐ HT  2 R (5‐ HT  2   A R  and 5‐ HT  2   B R ) expression in these two tissues as well as in skeletal muscle. Sarpogrelate or/and carbidopa treatment significantly abolished dexamethasone‐caused tissue‐specific  IR . In the liver, increased gluconeogenesis, triglycerides and very low‐density lipoprotein syntheses with steatosis, and downregulated expression of plasmalemmal glucose transporter‐2 were markedly reversed. In the visceral adipose and skeletal muscle, downregulated expression of plasmalemmal glucose transporter‐4 was significantly reversed, and increased lipolysis was also reversed in the visceral adipose. Dexamethasone‐induced activations of hepatic mammalian target of rapamycin serine 2448 , and S6K threonine 389/412  phosphorylation were also abolished markedly by sarpogrelate or/and carbidopa. Co‐treatment with sarpogrelate and carbidopa showed a synergistic effect on suppressing dexamethasone actions.    Conclusion  Inhibitions of both peripheral 5‐ HT  synthesis and 5‐ HT  2 R are expected to be a dependable target for treatment of steroid‐induced diabetes.

journal of diabetes investigation

Effective treatment with combination of peripheral 5‐hydroxytryptamine synthetic inhibitor and 5‐hydroxytryptamine 2 receptor antagonist on glucocorticoid‐induced whole‐body insulin resistance with hyperglycemia