Open AccessAssociation between interleukin‐19 and angiopoietin‐2 with vascular complications in type 2 diabetes
Author(s) -
Li Li,
ZHengQing Yu,
JuanYu Hu,
JianYong Xu,
Fan Liu,
GuangChun Zhao,
Lei Zhang,
HuiMing Gu,
SiJing Zhang,
Meng Jin
Publication year - 2016
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12519
Subject(s) - medicine , angiopathy , diabetes mellitus , type 2 diabetes mellitus , insulin resistance , type 2 diabetes , endocrinology , angiopoietin , hemoglobin , diabetic angiopathy , gastroenterology , vascular endothelial growth factor , vegf receptors
Abstract Aims/Introduction The aim of the present study was to investigate the role of interleukin‐19 ( IL ‐19) in angiogenesis of type 2 diabetes mellitus with complications, and to assess the relationship of serum IL ‐19 and angiopoietin‐2 (Ang‐2) in type 2 diabetes mellitus. Materials and Methods The group studied comprised of 240 patients with type 2 diabetes mellitus (132 men and 108 women), and included macrovascular complications, microvascular complications and type 2 diabetes mellitus without vascular complications. The control group consisted of 50 healthy blood donors. All participants were evaluated for: IL ‐19, Ang‐2, fasting plasma glucose, fasting insulin and glycosylated hemoglobin. Results The serum IL ‐19 levels of type 2 diabetes mellitus patients with angiopathy were found to be significantly higher compared with patients without angiopathy. IL ‐19 levels were significantly positively correlated with Ang‐2, homeostasis model assessment for insulin resistance and glycosylated hemoglobin ( r = 0.769, 0.523 and 0.491, respectively, P < 0.01). In multivariable logistic regression analysis, IL ‐19 levels ( P = 0.01) were found to be independently associated with patients with type 2 diabetes mellitus complications. Conclusions These data are the first to implicate the association between the IL ‐19 and type 2 diabetes mellitus with vascular complications. IL ‐19 is significantly positively correlated with Ang‐2. The potential role of IL ‐19 and Ang‐2 in the pathogenesis of vascular complications in type 2 diabetes could warrant further study.