Open AccessIncreased visceral adiposity with normal weight is associated with the prevalence of non‐alcoholic fatty liver disease in Japanese patients with type 2 diabetes
Author(s) -
Bouchi Ryotaro,
Takeuchi Takato,
Akihisa Momoko,
Ohara Norihiko,
Nakano Yujiro,
Nishitani Rie,
Murakami Masanori,
Fukuda Tatsuya,
Fujita Masamichi,
Minami Isao,
Mihara Masatomo,
Yoshimoto Takanobu,
Ogawa Yoshihiro
Publication year - 2016
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12443
Subject(s) - medicine , fatty liver , body mass index , confidence interval , gastroenterology , type 2 diabetes , odds ratio , logistic regression , diabetes mellitus , endocrinology , disease
Aims/Introduction To investigate the impact of increased visceral adiposity with normal weight ( OB [−] VA [+]) on the prevalence of non‐alcoholic fatty liver disease in patients with type 2 diabetes. Materials and Methods This was a cross‐sectional study of 140 Japanese patients with type 2 diabetes (mean age 65 ± 11 year; 44.6% women). Visceral fat area ( VFA ; cm 2 ) and liver attenuation index ( LAI ) were assessed by abdominal computed tomography. The patients were divided into four groups by VFA and body mass index ( BMI ; kg/m 2 ) as follows: BMI <25 kg/m 2 and VFA <100 cm 2 ( OB [−] VA [−]), BMI ≥25 kg/m 2 and VFA <100 cm 2 ( OB [+] VA [−]), BMI <25 kg/m 2 and VFA ≥100 cm 2 ( OB [−] VA [+]), and BMI ≥25 kg/m 2 and VFA ≥100 cm 2 ( OB [+] VA [+]). Multivariate linear regression and logistic regression analysis were carried out to determine the impact of OB (−) VA (+) on LAI . Results In the present study, 25.0% were OB (−) VA (+) patients, where the LAI levels were lower (1.09 ± 0.22) than those in OB (−) VA (−) patients (1.23 ± 0.15), and were equivalent to those in OB (+) VA (+) patients (1.03 ± 0.26). In multivariate linear regression analysis, OB (−) VA (+) was independently associated with LAI (standardized β−0.212, P = 0.014). In multivariate logistic regression analysis, OB (−) VA (+) was a significant predictor of LAI <0.9 (odds ratio 5.88, 95% confidence interval 1.03−33.52, P = 0.046). Conclusions The present study provides evidence that increased visceral adiposity with normal weight is a strong predictor for the prevalence of non‐alcoholic fatty liver disease in Japanese patients with type 2 diabetes.