Open AccessAssociation of salivary alpha 2‐macroglobulin levels and clinical characteristics in type 2 diabetes
Author(s) -
Chung TsungJu,
Hsu KaiYuen,
Chen JuiHung,
Liu JhihSyuan,
Chang HsiaoWen,
Li PengFei,
Huang ChiaLuen,
Shieh YiShing,
Lee ChienHsing
Publication year - 2016
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12382
Subject(s) - medicine , diabetes mellitus , glycated hemoglobin , endocrinology , triglyceride , saliva , cholesterol , type 2 diabetes , periodontitis , type 2 diabetes mellitus , hemoglobin , gastroenterology
Aims/Introduction Studies suggest that salivary proteins can be used as potential non‐invasive markers for clinical diagnosis and screening for diabetes. Previous reports showed that plasma alpha 2‐macroglobulin (A2 MG ) levels were higher in diabetic patients, especially with diabetic complications. We investigated the relationship between salivary A2 MG values and clinical characteristics in patients with type 2 diabetes. Materials and Methods A total of 91 adults were recruited from our outpatient clinics. The study the patients' collected general and biochemical data, and blood glucose (fasting glucose, glycated hemoglobin [HbA1c]) data. Plasma and salivary A2 MG levels were examined by enzyme‐linked immunosorbent assay. Results The salivary A2 MG levels were significantly positively correlated with plasma A2 MG levels, fasting glucose HbA1c and periodontitis status. After 3 months of follow up, the net change of salivary A2 MG values positively correlated with the net change of fasting glucose, HbA1c and triglyceride levels, but negatively correlated with high‐density lipoprotein cholesterol changes. Furthermore, the correlations between salivary A2 MG and fasting glucose HbA1c were better than plasma A2 MG , respectively. Conclusions Our data show that salivary A2 MG levels have better correlation with fasting glucose HbA1c and periodontitis status than plasma A2 MG in diabetic patients. Salivary A2 MG concentration might serve as a non‐invasive marker for clinical diabetic control.