Open AccessEffect of serum 25‐hydroxyvitamin D 3 on insulin resistance and β‐cell function in newly diagnosed type 2 diabetes patients
Author(s) -
Yang Yan,
Zhang Xuejun,
Bao Mingjing,
Liu Limei,
Xian Yang,
Wu Jichuan,
Li Pengqiu
Publication year - 2016
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12381
Subject(s) - insulin resistance , medicine , type 2 diabetes , diabetes mellitus , endocrinology , insulin , vitamin d and neurology , hemoglobin , gastroenterology , homeostasis
Aims/Introduction To evaluate serum 25‐hydroxyvitamin D 3 (25( OH )D 3 ) in newly diagnosed type 2 diabetes patients and to explore the associations of 25( OH )D 3 with insulin resistance and β‐cell function. Materials and Methods A total of 97 newly diagnosed type 2 diabetes patients and 69 healthy controls were recruited. Serum 25( OH )D 3 was determined using high‐pressure liquid chromatography. Insulin resistance was measured using a homeostasis model assessment of insulin resistance ( HOMA ‐ IR ). β‐Cell function was determined using the HOMA β‐cell function index ( HOMA ‐β), early‐phase insulin secretion index (ΔI30/ΔG30) and area under the insulin curve ( AUC ins). Correlation analysis was carried out using Pearson's correlation and multiple stepwise regression analysis. Results Serum 25( OH )D 3 was much lower in patients with newly diagnosed type 2 diabetes ( t = −13.00, P < 0.01), and the prevalence of hypovitaminosis 25( OH )D 3 was 62.9% (61/97) in diabetic patients. Among the diabetic patients, patients with hypovitaminosis 25( OH )D 3 showed higher glycosylated hemoglobin and AUC glu ( P < 0.01) as well as lower HOMA ‐β, ΔI30/ΔG30 and AUC ins. Serum 25( OH )D 3 was independently positively correlated with ΔI30/ΔG30 and AUC ins ( P < 0.05), but was not significantly correlated with either HOMA ‐ IR or HOMA ‐β. Only triglycerides, glycosylated hemoglobin and ΔI30/ΔG30 emerged as independent factors associated with serum 25( OH )D 3 in both diabetes patients and the health control group. Conclusions The present results further showed a low serum 25( OH )D 3 concentration in patients with newly diagnosed type 2 diabetes. 25( OH )D 3 deficiency is associated with disturbances in glucose metabolism and lipid metabolism. Serum 25( OH )D 3 is not correlated with basal insulin resistance or β‐cell function, but is significantly positively correlated with glucose‐stimulated insulin secretion and β‐cell function.