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Aims/Introduction  Variants in cell cycle regulation genes,   CDKAL 1  and   CDKN 2 A /2 B  , have been suggested to be associated with type 2 diabetes, and also play a role in insulin procession in non‐diabetic  E uropean individuals. Rs7754580 in   CDKAL 1  and rs7020996 in   CDKN 2 A /2 B   were found to be associated with gestational diabetes in  C hinese individuals. In order to understand the metabolism mechanism of greatly upregulated maternal insulin signaling during pregnancy and the pathogenesis of gestational diabetes, we investigated the impact of rs7754580 and rs7020996 on gestational insulin regulation and procession.    Materials and Methods  We recruited 1,146 unrelated, non‐diabetic, pregnant  H an  C hinese women (age 28.5 ± 4.1 years, body mass index 21.4 ± 2.6 kg/m 2 ), and gave them oral glucose tolerance tests. The indices of insulin sensitivity, insulin disposition, insulin release and proinsulin to insulin conversion were calculated. Rs7754580 in the   CDKAL 1  gene and rs7020996 in the   CDKN 2 A /2 B   gene were genotyped. Under an additive model, we analyzed the associations between the variants and gestational insulin indices using logistic regression.    Results  By adjusting for maternal age, body mass index and the related interactions,   CDKAL 1  rs7754580 risk allele  C  was detected to be associated with increased insulin sensitivity ( P  = 0.011), decreased insulin disposition ( P  = 0.0002) and 2‐h proinsulin conversion ( P  = 0.017).   CDKN 2 A /2 B   rs7020996 risk allele  T  was found to be related to decreased insulin sensitivity ( P  = 0.002) and increased insulin disposition ( P  = 0.0001).    Conclusions  The study showed that cell cycle regulating genes might have a distinctive effect on gestational insulin sensitivity, β‐cell function and proinsulin conversion in pregnant  H an  C hinese women.

Association of variants in CDKN2A/2B and CDKAL1 genes with gestational insulin sensitivity and disposition in pregnant Han Chinese women