Open AccessHigh‐normal urinary albumin‐to‐creatinine ratio is independently associated with metabolic syndrome in C hinese patients with type 2 diabetes mellitus: A cross‐sectional community‐based study
Author(s) -
Li MeiFang,
Feng QiMing,
Li LianXi,
Tu YinFang,
Zhang Rong,
Dong XueHong,
Lu JunXi,
Bao YuQian,
Jia WeiPing,
Hu RenMing
Publication year - 2015
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12307
Subject(s) - medicine , quartile , microalbuminuria , confounding , creatinine , type 2 diabetes mellitus , diabetes mellitus , logistic regression , type 2 diabetes , metabolic syndrome , albuminuria , endocrinology , confidence interval
Aims/Introduction Microalbuminuria is positively related to metabolic syndrome (MetS). Our aim was to investigate whether urinary albumin‐to‐creatinine ratio ( UACR ) within the normal range is independently associated with MetS in Chinese community‐based patients with type 2 diabetes. Materials and Methods A total of 514 participants (206 males and 308 females; mean age 66 years) with UACR less than 3.5 mg/mmol were enrolled from two downtown areas of Shanghai. The participants were stratified into quartiles according to UACR levels. The prevalence of MetS was assessed and compared among the four groups by binary logistic regression. Results Compared with participants with UACR s in the first quartile, the other quartiles had a higher prevalence of MetS (65.9%, 74.4% and 81.3%, respectively, P = 0.001) after adjustment for sex and age. After adjusting for potential confounders, participants in the second to the fourth quartile group had a 1.36‐, 1.84‐ and 2.73‐fold risk of MetS, respectively, relative to those in the lowest quartile. Furthermore, UACR , whether as quartile groups or as a continuous variable, is an independent predictor of MetS after fully adjusting for other variables. Conclusions These results suggest that UACR even within the normal range is independently associated with MetS in Chinese community‐based patients with type 2 diabetes mellitus.