Open AccessRapid onset of syndrome of inappropriate antidiuretic hormone secretion induced by duloxetine in an elderly type 2 diabetic patient with painful diabetic neuropathy
Author(s) -
Kamei Shinji,
Kaneto Hideaki,
Tanabe Akihito,
Irie Shintaro,
Hirata Yurie,
Shimoda Masashi,
Kohara Kenji,
Mune Tomoatsu,
Kaku Kohei
Publication year - 2015
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12301
Subject(s) - duloxetine , medicine , endocrinology , diabetes mellitus , antidiuretic , type 2 diabetes mellitus , diabetic neuropathy , peripheral neuropathy , hormone , type 2 diabetes , alternative medicine , pathology
Diabetic neuropathy is the most common diabetic complication. Duloxetine, a serotonin noradrenaline reuptake inhibitor ( SNRI ), is widely used for the treatment of diabetic painful neuropathy ( DPN ) because of the efficacy and safety profile. Syndrome of inappropriate antidiuretic hormone secretion, which is strongly associated duloxetine, is a rare but occasionally life‐threatening adverse effect. Here, we report a case of syndrome of inappropriate antidiuretic hormone secretion that rapidly developed after starting duloxetine in an elderly Japanese female type 2 diabetes mellitus patient. Furthermore, we discuss the possible relationship between the onset of syndrome of inappropriate antidiuretic hormone secretion and the gene polymorphism of cytochrome P450 isoform 1A2 and 2D6, both of which are responsible for duloxetine metabolism.