Open AccessMitochondrial reactive oxygen species in the pathogenesis of early diabetic nephropathy
Author(s) -
Nishikawa Takeshi,
Brownlee Michael,
Araki Eiichi
Publication year - 2015
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12258
Subject(s) - medicine , reactive oxygen species , diabetes mellitus , pathogenesis , diabetic nephropathy , nephropathy , bioinformatics , endocrinology , microbiology and biotechnology , biology
Dugan et al . reported model of a feed‐forward cycle involving decreased AMPK activity and decreased mitochondrial biogenesis caused by decreased ROS as a proposed mechanism involved in the pathogenesis of diabetic nephropathy. However, in this commentary, we proposed an alternate model of a feed‐forward cycle involving decreased AMPK activity and decreased mitochondrial biogenesis caused by increased mitochondrial ROS.