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Aims/Introduction  Diabetic dyslipidemia is common in type 2 diabetes. The  Taq IB   polymorphism in cholesteryl ester transfer protein ( CETP ; B1 and B2 alleles; rs708272) is associated with changes in enzyme activity and lipid concentrations. The aim of the present study was to assess associations of   CETP   genotypes with lipoprotein profile, oxidant/anti‐oxidant status and the plasma activity of paraoxonase‐1 ( PON ‐1) in a population of diabetic patients living in  S an  L uis,  A rgentina.    Materials and Methods  For oxidative stress status parameters, thiobarbituric acid‐reactive substances ( TBARS ) and nitric oxide ( NO ) levels, and catalase and  PON ‐1 activity were assessed in 40 patients with type 2 diabetes mellitus and 30 healthy participants.   CETP   polymorphism was analyzed by polymerase chain reaction‐based methods.    Results  Type 2 diabetes mellitus had significantly higher concentrations of oxidative stress parameters:  TBARS  ( P  < 0.0001) and catalase activity ( P  < 0.0001).  PON ‐1 activity and  NO  levels were significantly lower in diabetics ( P  = 0.0002 and  P  = 0.0008, respectively). The   CETP   genotypes distribution among study groups was not significantly different. The B2 carriers of the  Taq IB CETP   polymorphism are associated with higher high‐density lipoprotein cholesterol levels and  PON ‐1 activity in control and type 2 diabetes mellitus patients. Linear regression analysis showed that there was a significant and positive correlation between the changes of  PON ‐1 activity and high‐density lipoprotein cholesterol levels in non‐B1B1 (B2 carriers) in controls ( r  = 0.83,  P  < 0.0001) and diabetic patients ( r  = 0.39,  P  = 0.0003).    Conclusions  The results of the current study show that type 2 diabetes mellitus is characterized by intense oxidative stress, and that the alterations observed in the lipoprotein profile and  PON ‐1 activity might be related to the higher  CETP  activity in diabetic patients as a consequence of insulin resistance.

journal of diabetes investigation

Association of cholesteryl ester transfer protein genotypes with paraoxonase‐1 activity, lipid profile and oxidative stress in type 2 diabetes mellitus: A study in  S an  L uis,  A rgentina