Open AccessDiabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damage
Author(s) -
Liu Quan,
Wang Shudong,
Cai Lu
Publication year - 2014
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12250
Subject(s) - medicine , oxidative stress , pathogenesis , diabetic cardiomyopathy , diabetes mellitus , cardiomyopathy , disease , hyperlipidemia , inflammation , bioinformatics , pathological , cardiology , heart failure , endocrinology , biology
Diabetic cardiomyopathy as an important threat to health occurs with or without coexistence of vascular diseases. The exact mechanisms underlying the disease remain incompletely clear. Although several pathological mechanisms responsible for diabetic cardiomyopathy have been proposed, oxidative stress is widely considered as one of the major causes for the pathogenesis of the disease. Hyperglycemia‐, hyperlipidemia‐, hypertension‐ and inflammation‐induced oxidative stress are major risk factors for the development of microvascular pathogenesis in the diabetic myocardium, which results in abnormal gene expression, altered signal transduction and the activation of pathways leading to programmed myocardial cell deaths. In the present article, we aim to provide an extensive review of the role of oxidative stress and anti‐oxidants in diabetic cardiomyopathy based on our own works and literature information available.