z-logo
open-access-imgOpen Access
One size does not fit all glycemic targets for type 2 diabetes
Author(s) -
Pozzilli Paolo,
Strollo Rocky,
Bonora Enzo
Publication year - 2014
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12206
Subject(s) - medicine , glycemic , diabetes mellitus , type 2 diabetes , natural history , intensive care medicine , disease , clinical trial , macrovascular disease , randomized controlled trial , endocrinology
The U nited K ingdom P rospective D iabetes S tudy, and D iabetes C ontrol and C omplications Trial have shown that aggressive glucose control, especially early in the natural history of the disease, might result in a significant reduction of microvascular as well as macrovascular complications. However, more recent trials have increased the level of complexity of the relationship between ‘tight glucose control/chronic complications’, with several factors influencing the risk‐to‐benefit ratio to be considered, such as age, presence of established complications and diabetes duration. According to this strategy, a more intensive goal is desirable for young patients with no cardiovascular disease, whereas less stringent control is suitable for all people who are relatively late in the natural history of diabetic complications. Numerous calls for an individualized therapy have been proposed during the past years, but still debated is the level of glucose lowering necessary to reduce complications balanced by the risk and costs of the means used. The present paper briefly reviews the rationale and the clinical trials that support specific glycemic goals towards a ‘tailored’ approach for the management of hyperglycemia in diabetes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here