Open AccessComparison of three α‐glucosidase inhibitors for glycemic control and bodyweight reduction in J apanese patients with obese type 2 diabetes
Author(s) -
Sugihara Hitoshi,
Nagao Mototsugu,
Harada Taro,
Nakajima Yasushi,
TanimuraInagaki Kyoko,
Okajima Fumitaka,
Tamura Hideki,
Inazawa Takeshi,
Otonari Takatoshi,
Kawakami Masanobu,
Oikawa Shinichi
Publication year - 2014
Publication title -
journal of diabetes investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.089
H-Index - 50
eISSN - 2040-1124
pISSN - 2040-1116
DOI - 10.1111/jdi.12135
Subject(s) - medicine , type 2 diabetes , glycemic , acarbose , adiponectin , endocrinology , diabetes mellitus , glycated hemoglobin , body mass index , blood lipids , type 2 diabetes mellitus , adipokine , cholesterol , insulin resistance
Abstract Aims/Introduction α‐Glucosidase inhibitors (α GI s) are widely used for the primary treatment of type 2 diabetes. We compared the clinical effects of three α GI s (miglitol, acarbose and voglibose) in patients with obese type 2 diabetes. Materials and Methods Japanese patients ( n = 81) with obese type 2 diabetes (body mass index [ BMI ] ≥25 kg/m 2 ) were enrolled in this multicenter, open‐label study. The participants were randomized into the miglitol ( n = 18), acarbose ( n = 22), voglibose ( n = 19) or control ( n = 22) groups. Glycemic control (fasting blood glucose and glycated hemoglobin [HbA1c]), bodyweight, BMI , serum insulin, serum lipids (low‐density lipoprotein and high‐density lipoprotein cholesterol, and triacylglycerols) and adipocytokines (leptin and adiponectin) were evaluated every 4 weeks for 12 weeks. Results In the miglitol group, H b A 1c was improved significantly from the baseline at all points. The changes in H b A 1c at 8 and 12 weeks from baseline were greater in the miglitol group than the control group. The voglibose group showed significant improvements in H b A 1c at 12 weeks. Bodyweight and BMI were decreased significantly in the miglitol group. In addition, significant correlations were observed between the decrements in H b A 1c and bodyweights over 12 weeks in the miglitol ( r = 0.759, P < 0.001) and voglibose groups ( r = 0.667, P = 0.002). Serum lipid and adipocytokine levels were not altered in any groups. Conclusions α GI s, especially miglitol, can effectively control blood glucose and bodyweight in obese type 2 diabetes. This study was registered with UMIN (no. UMIN 6465).