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Aims/Introduction  Mean platelet volume ( MPV ) reflects platelet activity, and high  MPV  is associated with thrombogenic activation and increased cardiovascular disease risk. Although a positive correlation between  MPV  and fasting plasma glucose ( FPG ) levels has been reported, the correlation between  MPV  and postprandial glucose levels remains unclear. The purpose of the present study was to evaluate the correlation between  MPV  and postprandial glucose levels in prediabetic and normoglycemic participants.    Materials and Methods  We evaluated 1,080 Japanese participants who underwent the 75‐g oral glucose tolerance test ( OGTT ). Based on these results, the participants were divided into three groups: normal glucose tolerance group ( NGT ;  n  = 582), impaired fasting glucose group ( IFG ;  n  = 205) and impaired glucose tolerance group ( IGT ;  n  = 252). The relationship between  MPV ,  FPG , and postchallenge glucose levels after 1 h (1 h‐ PG ) and 2 h (2 h‐ PG ) were analyzed.    Results  Bivariate correlation analyses showed a significant positive correlation between  MPV  and both  FPG  and 1 h‐ PG  levels in the  NGT  group, as well as between  MPV  and 2 h‐ PG , total cholesterol, and low‐density lipoprotein cholesterol in the  IGT  group. In contrast, no significant correlation was observed between  MPV  and postchallenge glucose levels in the  IFG  group. Multiple correlation analyses showed that  FPG  levels significantly correlated with  MPV  in the  NGT  and  IGT  groups. In addition, 1 h‐ PG  and 2 h‐ PG  levels correlated with  MPV  in the  NTG  and  IGT  groups, respectively.    Conclusions  These results suggest a possible mechanism by which subjects with postprandial hyperglycemia might be at increased cardiovascular risk.

Correlation between mean platelet volume and blood glucose levels after oral glucose loading in normoglycemic and prediabetic J apanese subjects