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The effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: Meta‐analysis of eighteen randomized controlled trials
Author(s) -
Biesbrock Aaron,
He Tao,
DiGennaro Joe,
Zou Yuanshu,
Ramsey Dave,
GarciaGodoy Franklin
Publication year - 2019
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.13203
Subject(s) - dentifrice , gingivitis , randomized controlled trial , triclosan , medicine , bioavailability , odds ratio , fluoride , dentistry , meta analysis , negative control , gastroenterology , chemistry , traditional medicine , pharmacology , inorganic chemistry , pathology
Aim To estimate gingivitis effects of a bioavailable gluconate chelated 0.454% stannous fluoride (SnF 2 ) family of dentifrices in adult subjects versus positive (triclosan) and negative (NaF or MFP) controls when used ≤3 months. Materials and methods A meta‐analysis evaluated bioavailable gluconate chelated SnF 2 dentifrices versus a negative or positive control for gingival bleeding. Results In 18 randomized controlled trials (RCTs) with 2,890 subjects assessing SnF 2 paste versus a negative or positive control, the average number of bleeding sites was reduced by 51% and 31%, respectively. The average change (95% CI) in number of bleeding sites was −16.3 (−27.8, −4.9) versus the negative control and −3.6 (−5.4, −1.8) versus the positive control. Subjects with localized or generalized gingivitis had 3.7 times better odds (95% CI [2.8, 5.0]) of shifting to generally healthy using SnF 2 versus a negative control and 2.8 times better odds (95% CI [2.1, 3.9]) of shifting to generally healthy using SnF 2 versus a positive control. The individual study risk of bias was deemed to be low in all categories of bias. Conclusion This meta‐analysis demonstrates significant gingivitis benefits of bioavailable SnF 2 dentifrices when used ≤3 months versus positive (triclosan) and negative (NaF or MFP) controls.

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