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Aim  To estimate gingivitis effects of a bioavailable gluconate chelated 0.454% stannous fluoride (SnF 2 ) family of dentifrices in adult subjects versus positive (triclosan) and negative (NaF or MFP) controls when used ≤3 months.    Materials and methods  A meta‐analysis evaluated bioavailable gluconate chelated SnF 2  dentifrices versus a negative or positive control for gingival bleeding.    Results  In 18 randomized controlled trials (RCTs) with 2,890 subjects assessing SnF 2  paste versus a negative or positive control, the average number of bleeding sites was reduced by 51% and 31%, respectively. The average change (95% CI) in number of bleeding sites was −16.3 (−27.8, −4.9) versus the negative control and −3.6 (−5.4, −1.8) versus the positive control. Subjects with localized or generalized gingivitis had 3.7 times better odds (95% CI [2.8, 5.0]) of shifting to generally healthy using SnF 2  versus a negative control and 2.8 times better odds (95% CI [2.1, 3.9]) of shifting to generally healthy using SnF 2  versus a positive control. The individual study risk of bias was deemed to be low in all categories of bias.    Conclusion  This meta‐analysis demonstrates significant gingivitis benefits of bioavailable SnF 2  dentifrices when used ≤3 months versus positive (triclosan) and negative (NaF or MFP) controls.

journal of clinical periodontology

The effects of bioavailable gluconate chelated stannous fluoride dentifrice on gingival bleeding: Meta‐analysis of eighteen randomized controlled trials