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Three randomized studies of dentine hypersensitivity reduction after short‐term SnF 2 toothpaste use
Author(s) -
Creeth Jonathan,
Maclure Robert,
Seong Joon,
GomezPereira Paola,
Budhawant Chandrashekhar,
Sufi Farzana,
Holt Jonathan,
Chapman Nicholas,
West Nicola
Publication year - 2019
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.13175
Subject(s) - toothpaste , dentine hypersensitivity , dentistry , medicine , dentifrice , randomized controlled trial , sodium fluoride , visual analogue scale , fluoride , surgery , chemistry , inorganic chemistry
Aim To evaluate effects of a 0.454% stannous fluoride test toothpaste on dentine hypersensitivity (DH) applied by fingertip, then 3 days’ brushing, versus a sodium monofluorophosphate‐based control. Materials and Methods In three randomized clinical studies, DH was assessed using evaporative (Schiff scale) and tactile (Yeaple probe) stimuli. Participants applied toothpaste to two sensitive teeth by fingertip (60 s each); DH was re‐assessed, prior to brushing. Test treatment participants brushed their sensitive teeth, with all participants then brushing all teeth for ≥60 s, twice daily for 3 days. DH was re‐assessed. Data were analysed by study and then pooled. Results In two studies, test treatment significantly reduced DH versus control treatment after fingertip application and 3 days’ brushing (both measures). In one study, both treatments significantly reduced DH without between‐treatment differences. Mean Schiff differences (95% confidence intervals) for fingertip/3d were as follows: Study 1: −0.09 (−0.280, 0.092)/ −0.18 (−0.442, 0.072); Study 2: −0.72 (−0.839, −0.610)/ −1.02 (−1.150, −0.882); and Study 3: −0.26 (−0.387, −0.123)/ −0.92 (−1.055, −0.793). Pooled analysis indicated test treatment significantly reduced DH versus control (both timepoints, both measures). Toothpastes were generally well‐tolerated. Conclusion Studies indicated that single, fingertip application of a SnF 2 toothpaste reduced DH versus a control. DH relief increased over 3 days.