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Aim  Periodontitis is a chronic inflammatory disease, characterized by irreversible destruction of tooth‐supporting tissue including alveolar bone. We recently reported mucin 4 ( MUC 4) and matrix metalloproteinase 7 ( MMP 7) as highly associated with periodontitis in gingival tissue biopsies. The aim of this study was to further investigate the levels of  MUC 4 and  MMP 7 in saliva and gingival crevicular fluid ( GCF ) samples of patients with periodontitis.    Materials and Methods  Saliva and  GCF  samples were collected from periodontitis patients and healthy controls. The levels of  MUC 4,  MMP 7, and total protein concentrations were analysed using  ELISA  or Bradford assay.    Results   MUC 4 levels were significantly lower in saliva and  GCF  from periodontitis patients relative to healthy controls.  MMP 7 levels were significantly higher in saliva and  GCF  from periodontitis patients. Multivariate analysis revealed that  MUC 4 was significantly associated with periodontitis after adjusting for age and smoking habits and, moreover, that the combination of  MUC 4 and  MMP 7 accurately discriminated periodontitis from healthy controls.    Conclusions   MUC 4 and  MMP 7 may be utilized as possible novel biomarkers for periodontitis.

Mucin 4 and matrix metalloproteinase 7 as novel salivary biomarkers for periodontitis