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Aim  The aim of this study was to evaluate the effect of telmisartan ( TELM ) on inflammation, oxidation and the expression of matrix metalloproteinases ( MMP s) and the expression  RANKL / RANK / OPG  in the periodontal tissue of a rat model for ligature‐induced periodontitis.    Materials and methods  Male Wistar albino rats were randomly divided into five groups of 10 rats each: (i) non‐ligated, given water; (ii) ligated, given water; (iii) ligated, given 1 mg/kg  TELM ; (iv) ligated, given 5 mg/kg  TELM ; and (v) ligated, given 10 mg/kg  TELM . All groups were treated with saline or  TELM  for 10 days. Periodontal tissue was analysed by histopathology; by the immunohistochemical examination of  COX ‐2,  MMP ‐2,  MMP ‐9 and the  RANKL / RANK / OPG  pathway; and by  ELISA  analysis of the levels of  IL ‐1β,  IL ‐10,  TNF ‐α, myeloperoxidase ( MPO ), malonaldehyde ( MDA ) and glutathione ( GSH ).    Results  Treatment with 10 mg/kg  TELM  resulted in reduced concentrations of  MPO ,  MDA  ( p  < 0.05) and the pro‐inflammatory cytokine  IL ‐1β ( p  < 0.05); reduced expression of  MMP ‐2,  MMP ‐9,  RANK ,  RANKL  and  COX ‐2; and an increase in  OPG . The levels of  TNF ‐α were significantly reduced in all  TELM ‐treated groups.    Conclusions  These findings confirm the involvement of  TELM  in reducing the inflammatory response, oxidative stress and bone loss in ligature‐induced periodontitis in rats.

Effect of telmisartan on levels of IL ‐1, TNF ‐α, down‐regulated COX ‐2, MMP ‐2, MMP ‐9 and RANKL / RANK in an experimental periodontitis model