Open AccessAssociation between serum manganese levels and diabetes in Chinese adults with hypertension
Author(s) -
Chen Hong,
Cui Zhixin,
Lu Wenhai,
Wang Ping,
Wang Jia,
Zhou Ziyi,
Zhang Nan,
Wang Zhuo,
Lin Tengfei,
Song Yun,
Liu Lishun,
Huang Xiao,
Chen Ping,
Tang Genfu,
Duan Yong,
Wang Binyan,
Zhang Hao,
Xu Xiping,
Yang Yan,
Qin Xianhui,
Song Fenglin
Publication year - 2022
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.14520
Subject(s) - medicine , diabetes mellitus , odds ratio , confidence interval , logistic regression , cross sectional study , population , manganese , endocrinology , environmental health , pathology , chemistry , organic chemistry
Manganese (Mn) is an essential trace metal element that is associated with diabetes; however, the results of previous studies are inconsistent. Furthermore, few studies have been conducted in a hypertensive population. The purpose of this study is to explore the relationship between manganese and diabetes in a population with hypertension. A cross‐sectional study was conducted, including 2575 hypertensive individuals from 14 provinces in China. Serum manganese concentrations were measured by the inductively coupled plasma mass spectrometry (ICP‐MS) method. And logistic regression models were used to analyze the association between serum manganese and the risk of diabetes. The prevalence of diabetes was 27.0% in this hypertensive population. In logistic regression models, the odds ratios (95% confidence interval) for diabetes in tertile subgroups were 1.40 (1.12, 1.76) and 1.32 (1.05, 1.65) for tertiles 1 and tertiles 3, respectively, compared to tertile 2 (reference). Additionally, an interaction between sex and manganese was observed. The odds ratios (95% confidence interval) for diabetes were 1.29 (0.95, 1.75) and 0.96 (0.70, 1.31) for tertiles 1 and tertiles 3 among males, and 1.44 (1.01, 2.04) and 1.81 (1.29, 2.55) for tertiles 1 and tertiles 3 among females, respectively, compared to tertile 2. In conclusion, a U‐shaped association between serum manganese and diabetes was observed in a Chinese population with hypertension, and the association was modified by sex.