Open AccessAssessment of preferred methods to measure insulin resistance in Asian patients with hypertension
Author(s) -
Minh Huynh Van,
Tien Hoang Anh,
Sinh Cao Thuc,
Thang Doan Chi,
Chen ChenHuan,
Tay Jam Chin,
Siddique Saulat,
Wang TzungDau,
Sogunuru Guru Prasad,
Chia YookChin,
Kario Kazuomi
Publication year - 2021
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.14155
Subject(s) - medicine , insulin resistance , gold standard (test) , clamp , homeostatic model assessment , triglyceride , insulin , risk factor , intensive care medicine , cholesterol , mechanical engineering , clamping , engineering
Insulin resistance (IR), a metabolic risk factor, is linked to the pathogenetic mechanism of primary hypertension. Detecting IR in the patients with hypertension will help to predict and stratify the added cardiovascular risk, institute appropriate IR management, and manage hypertension optimally. There are many methods for assessing IR, each with distinct advantages and disadvantages. The euglycemic insulin clamp and intravenous glucose tolerance test, gold standards for measuring IR, are used in research but not in clinical practice. Homeostatic model assessment (HOMA‐IR), a method for assessing β‐cell function and IR, is frequently applied presently, particularly in Asia. Besides, the triglyceride–glucose index (TyG) first published by South American authors showed a good correlation with the insulin clamp technique and HOMA‐IR index. This simple, convenient, and low‐cost TyG index is of research interest in many countries in Asia and can be used to screen for IR in the Asian hypertensive community.