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Aims  This study investigates the antagonistic effects of the probiotic strains  Lactobacillus rhamnosus   GR ‐1 and  Lactobacillus reuteri   RC ‐14 against vulvovaginal candidiasis ( VVC )‐causing  Candida glabrata .    Methods and Results  Growth inhibitory activities of  Lact. rhamnosus   GR ‐1 and  Lact. reuteri   RC ‐14 strains against  C. glabrata  were demonstrated using a spot overlay assay and a plate‐based microtitre assay. In addition, these probiotic lactobacilli strains also exhibited potent candidacidal activity against  C. glabrata , as demonstrated by a  LIVE / DEAD  yeast viability assay performed using confocal laser scanning microscopy. The metabolic activities of all  C. glabrata  strains were completely shut down in response to the challenges by the probiotic lactobacilli strains. In addition, both probiotic lactobacilli strains exhibited strong autoaggregation and coaggregation phenotypes in the presence of  C. glabrata , which indicate that these lactobacilli strains may exert their probiotic effects through the formation of aggregates and, thus the consequent prevention of colonization by  C. glabrata .    Conclusions  Probiotic  Lact. rhamnosus   GR ‐1 and  Lact. reuteri   RC ‐14 strains exhibited potent antagonistic activities against all of the tested  C. glabrata  strains. These lactobacilli exhibited antifungal effects, including those attributed to their aggregation abilities, and their presence caused the cessation of growth and eventual cell death of  C. glabrata .    Significance and Impact of the Study  This is the first study to report on the antagonistic effects of these probiotic lactobacilli strains against the non‐ Candida albicans Candida  ( NCAC ) species  C. glabrata .

journal of applied microbiology

Probiotic   L actobacillus rhamnosus   GR ‐1 and   L actobacillus reuteri   RC ‐14 exhibit strong antifungal effects against vulvovaginal candidiasis‐causing   C andida glabrata  isolates