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Transduction of corneal endothelial cells with AAV2 vectors
Author(s) -
Gruenert A.
Publication year - 2016
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2016.0121
Subject(s) - transduction (biophysics) , corneal endothelium , cornea , endothelial stem cell , endothelium , microbiology and biotechnology , biology , signal transduction , genetics , neuroscience , biochemistry , in vitro
Summary This talk deals with transduction of corneal endothelial cells with different kinds of AAV2 vectors. Data of a human corneal endothelial cell line as well as of human donor cornea endothelium will be presented. Furthermore, ways of optimizing transduction efficiency and feasibility of AAV2‐mediated gene therapy will be discussed.