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Road to fulfillment (not perdition): taming immune response to restore vision
Author(s) -
DICK A
Publication year - 2011
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.2011.384.x
Subject(s) - inflammation , immune system , homeostasis , infiltration (hvac) , uveitis , retinal , retina , macular degeneration , myeloid cells , neuroscience , immunology , biology , medicine , microbiology and biotechnology , ophthalmology , physics , thermodynamics
Understanding immune regulation that maintains retinal function whilst interrogating immune responses during retinal inflammation has illuminated avenues to harness for future therapy of many disorders including uveitis and neovascular age‐related macular degeneration. The retina is endowed with a network of a continual turnover of myeloid derived cells. The default response is to regulate inflammation, however during inflammation the over burdening infiltration of activated T cells or macrophages generates damage and homeostasis is difficult to refirm. By harnessing approaches of suppressing infiltration via inhibiting trafficking of cells into the tissue, or inhibiting activation of cell infiltrate and then restoring homeostasis via recapitulating natural mechanisms of control will prevent damage, facilitate healing and regeneration and maintain immunoregulation.Commercial interest