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Tissue Growth and Remodeling of the Embryonic and Adult Adrenal Gland
Author(s) -
BLAND MICHELLE L.,
DESCLOZEAUX MARION,
INGRAHAM HOLLY A.
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2003.tb03210.x
Subject(s) - adrenal gland , adrenal cortex , endocrine system , biology , endocrinology , primordium , medicine , regeneration (biology) , adrenal medulla , hormone , microbiology and biotechnology , biochemistry , catecholamine , gene
A bstract : The adrenal gland provides a model system for the study of tissue remodeling in endocrine physiology. For example, proper adrenal development requires proliferation of the adrenogonadal primordia, separation of adrenal and gonadal precursors, and cell migration that unites the adrenal cortex and adrenal medulla. In the adult, normal adrenal function is assured by the adrenal gland's unique capacity for growth in response to both tissue injury and physiological demand. Identification of the molecular and genetic programs underlying tissue remodeling in the adrenal is important for understanding basic aspects of development and regeneration, as well as adrenal disease. Here, we will highlight the roles that nuclear receptors and pituitary hormones play in regulating fetal adrenal development and adult adrenal growth. In addition, we will review the most current data on how extracellular signaling pathways are coupled to the function of these important regulators of adrenal development and function.