Premium
Chromogranin A‐Activated Microglial Cells Induce Neuronal Apoptosis
Author(s) -
ULRICH GABRIELLE,
CIESIELSKITRESKA JAROSLAVA,
TAUPENOT LAURENT,
BADER MARIEFRANCE
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04527.x
Subject(s) - chromogranin a , microglia , apoptosis , microbiology and biotechnology , downregulation and upregulation , mitochondrion , p38 mitogen activated protein kinases , endogeny , programmed cell death , kinase , biology , neuroscience , protein kinase a , chemistry , inflammation , immunology , endocrinology , immunohistochemistry , biochemistry , gene
A bstract : Chromogranin (CgA), a protein upregulated in many neuropathologies, can induce an activated phenotype in microglial cells that leads to neuronal apoptosis. The death‐signaling pathways mobilized in neurons involve the death receptor Fas, p38 MAP kinase, and mitochondrial cytochrome c . We propose that CgA represents a potent endogenous inflammatory factor responsible for neuronal degeneration.