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A Critical Assessment of the Neurodestructive and Neuroprotective Effects of Nitric Oxide
Author(s) -
LEONG SENGKEE,
RUAN RUNSHENG,
ZHANG ZHI
Publication year - 2002
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2002.tb04066.x
Subject(s) - neuroprotection , nitric oxide , neuroscience , chemistry , pharmacology , medicine , psychology
A bstract : Whether nitric oxide is cytodestructive or cytoprotective is of obvious clinical importance. The debate on this subject in the past decade has generated much “heat and light”. This paper focuses on the actions of NO on the nervous system and reexamines the controversial issue and the contribution of the authors and their colleagues in the light of recent findings. We also report new findings, critically assesses previous experimental data, and share perspectives on this important subject.