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Genetic Factors in the Genesis of Alzheimer's Disease
Author(s) -
ST GEORGEHYSLOP P. H.
Publication year - 2000
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.2000.tb05552.x
Subject(s) - disease , gene , apolipoprotein e , genetics , biology , penetrant (biochemical) , alzheimer's disease , medicine , pathology , microbiology and biotechnology
A bstract : At least four different genes have been identified that are associated with inherited susceptibility to Alzheimer's disease. Some of the genes are highly penetrant (PS1, PS2, bAPP); the other, APOE, is a weaker susceptibility factor. Several additional genes are suspected to exist but have not yet been cloned.